Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | P4HB | P07237 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 2/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | XIAP | P98170 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6297966 | 1.00 | HTR2C (0.37) | HTR2CP4HBHTR2BHTR1ADRD2 | |
| SCHEMBL6297969 | 1.00 | HTR2C (0.37) | HTR2CP4HBHTR2BHTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL6300453 | 0.99 | HTR2C (0.36) | HTR2CP4HBHTR2BHTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL6300455 | 0.99 | HTR2C (0.36) | HTR2CP4HBHTR2BHTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL6300457 | 0.99 | HTR2C (0.36) | HTR2CP4HBHTR2BHTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL6304604 | 0.79 | LATS1 (0.40) | HTR2CHTR2BHTR2A | |
| Hydrochloric Acid SCHEMBL6298314 | 0.79 | LATS1 (0.40) | HTR2CHTR2BHTR2A | |
| Hydrochloric Acid SCHEMBL6305317 | 0.77 | HTR2C (0.55) | HTR2CXIAP | |
| Hydrochloric Acid SCHEMBL6298012 | 0.77 | HTR2C (0.55) | HTR2CXIAP | |
| Hydrochloric Acid SCHEMBL6300357 | 0.74 | HTR2C (0.38) | HTR2CHTR2BHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6967201-B1 | for increasing activation of the 5-HT2C receptor in mammals; treatment of depression, obesity, bulimia, premenstrual syndrome, alcoholism, tobacco abuse, panic disorder | ELI LILLY AND COMPANY (US) | 2005-11-22 | — | — | US | disclosed |
| EP-1204654-B1 | BENZOFURYLPIPERAZINES: 5-HT2C SEROTONIN RECEPTOR AGONISTS | LILLY CO ELI (US) | 2003-07-23 | — | — | EP | disclosed |