⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22102118 | 1.00 | — | — | |
| SCHEMBL6299911 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL29469830 | 0.97 | — | — | |
| SCHEMBL2644164 | 0.87 | — | — | |
| SCHEMBL1304445 | 0.87 | — | — | |
| SCHEMBL1266740 | 0.87 | — | — | |
| SCHEMBL20833338 | 0.85 | KDM4E (0.40) | — | |
| Hydrochloric Acid SCHEMBL15192972 | 0.85 | KDM4E (0.48) | — | |
| SCHEMBL16448784 | 0.85 | KDM4E (0.40) | — | |
| Hydrochloric Acid SCHEMBL1266559 | 0.85 | KDM4E (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107641114-B | Compound as isocitrate dehydrogenase inhibitor and application thereof | 南京圣和药业股份有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-109890806-B | Compound as isocitrate dehydrogenase inhibitor and application thereof | 南京圣和药业股份有限公司 | 2022-04-26 | — | — | CN | disclosed |
| EP-3489230-B1 | CHEMICAL COMPOUND OF ISOCITRATE DEHYDROGENASE INHIBITOR, AND APPLICATION THEREOF | NANJING SANHOME PHARMACEUTICAL CO LTD (CN) | 2021-12-08 | — | — | EP | disclosed |
| US-20210363152-A1 | AMINOAZINE AMIDES | HOFFMANN LA ROCHE (US) | 2021-11-25 | — | — | US | disclosed |
| US-10961222-B2 | Chemical compound of isocitrate dehydrogenase inhibitor, and application thereof | NANJING SANHOME PHARMACEUTICAL CO., LTD. (CN) | 2021-03-30 | — | — | US | disclosed |
| US-10961222-B2 | Chemical compound of isocitrate dehydrogenase inhibitor, and application thereof | NANJING SANHOME PHARMACEUTICAL CO., LTD. (CN) | 2021-03-30 | — | — | US | disclosed |
| US-20190161473-A1 | CHEMICAL COMPOUND OF ISOCITRATE DEHYDROGENASE INHIBITOR, AND APPLICATION THEREOF | NANJING SANHOME PHARMACEUTICAL CO., LTD. (CN) | 2019-05-30 | — | — | US | disclosed |
| US-20190161473-A1 | CHEMICAL COMPOUND OF ISOCITRATE DEHYDROGENASE INHIBITOR, AND APPLICATION THEREOF | NANJING SANHOME PHARMACEUTICAL CO., LTD. (CN) | 2019-05-30 | — | — | US | disclosed |
| EP-3489230-A1 | CHEMICAL COMPOUND OF ISOCITRATE DEHYDROGENASE INHIBITOR, AND APPLICATION THEREOF | Nanjing Sanhome Pharmaceutical Co., Ltd. (CN) | 2019-05-29 | — | — | EP | disclosed |
| WO-2018014852-A1 | CHEMICAL COMPOUND OF ISOCITRATE DEHYDROGENASE INHIBITOR, AND APPLICATION THEREOF | 南京圣和药业股份有限公司 | 2018-01-25 | — | — | WO | disclosed |
| US-8952185-B2 | Production method of optically active dihydrobenzofuran derivative | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-02-10 | — | — | US | disclosed |
| US-6930189-B2 | Chiral ligand | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2005-08-16 | — | — | US | disclosed |
| US-6762306-B2 | A N,O-BIS(DIPHENYLPHOSPHINO)-2-AZETIDINE DERIVATIVES, A TRANSITION METAL COMPLEX FOR USE AS HYDROGENATION CATALYSTS | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2004-07-13 | — | — | US | disclosed |
| US-20040110965-A1 | Chiral ligand | SUMITOMO CHEMICAL COMPANY, LIMITED | 2004-06-10 | — | — | US | disclosed |
| US-20030191324-A1 | Chiral ligand | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2003-10-09 | — | — | US | disclosed |
| EP-1241174-A1 | Chiral ligands for asymmetric synthesis | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2002-09-18 | — | — | EP | disclosed |