Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 6/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.42 |
| ▸ | TTK | P33981 | 2/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.40 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1461707 | 0.87 | ITK (0.52) | ITKMAPK1AURKANTRK1TTK | |
| SCHEMBL1461074 | 0.86 | BRD4 (0.50) | ITKMAPK1AURKANTRK1TTK | |
| SCHEMBL1460595 | 0.86 | ITK (0.48) | ITKMAPK1AURKANTRK1TTK | |
| SCHEMBL1459787 | 0.86 | ITK (0.58) | ITKMAPK1AURKANTRK1TTK | |
| SCHEMBL1461732 | 0.86 | AURKA (0.48) | ITKMAPK1AURKANTRK1TTK | |
| SCHEMBL1461015 | 0.85 | ITK (0.50) | ITKMAPK1AURKATTKAURKB | |
| SCHEMBL1460552 | 0.85 | MAPK1 (0.54) | ITKMAPK1AURKANTRK1TTK | |
| SCHEMBL1460748 | 0.84 | BRD4 (0.53) | ITKMAPK1AURKANTRK1AURKB | |
| SCHEMBL1461009 | 0.84 | ITK (0.47) | ITKMAPK1AURKANTRK1TTK | |
| SCHEMBL1460713 | 0.84 | BRD4 (0.50) | ITKMAPK1AURKANTRK1TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6858638-B2 | Substituted indazoles, compositions containing them, method of production and use | AVENTIS PHARMA S.A. (FR) | 2005-02-22 | — | — | US | claimed |