Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.68 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7000465 | 0.96 | PARP1 (0.67) | PARP1TP53POLBSMN1; SMN2KDR | |
| SCHEMBL6305046 | 0.90 | PARP1 (0.77) | PARP1TP53POLBSMN1; SMN2KDR | |
| SCHEMBL6996295 | 0.88 | PARP1 (0.78) | PARP1TP53POLBSMN1; SMN2KDR | |
| SCHEMBL6305288 | 0.87 | PARP1 (0.88) | PARP1TP53POLBSMN1; SMN2HSD17B10 | |
| SCHEMBL6304625 | 0.86 | PARP1 (0.75) | PARP1TP53POLBSMN1; SMN2KDR | |
| SCHEMBL6992288 | 0.86 | PARP1 (0.75) | PARP1TP53POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL6999731 | 0.85 | PARP1 (0.80) | PARP1TP53POLBSMN1; SMN2HSD17B10 | |
| SCHEMBL6310170 | 0.84 | PARP1 (0.95) | PARP1TP53POLBSMN1; SMN2HSD17B10 | |
| SCHEMBL6999765 | 0.84 | PARP1 (0.67) | PARP1TP53POLBSMN1; SMN2KDR | |
| SCHEMBL6309373 | 0.82 | PARP1 (0.76) | PARP1TP53POLBSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6841550-B1 | Benzoxazine and benzothiazine derivatives and their use in medicines | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-01-11 | — | — | US | disclosed |
| EP-1114037-B1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN MEDICINES | SCHERING AG (DE) | 2004-05-12 | — | — | EP | disclosed |