Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 0.65 |
| ▸ | PDE1A | P54750 | 4/20 | 0.54 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.54 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.54 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6311855 | 0.95 | PDE5A (0.59) | PDE5AADORA2BPDE3BPDE3AADORA3 | |
| SCHEMBL6307678 | 0.94 | PDE5A (0.66) | PDE5APDE1APDE1BPDE1CADORA2B | |
| SCHEMBL6305249 | 0.93 | PDE5A (0.63) | PDE5APDE1APDE1BPDE1CADORA2B | |
| SCHEMBL6305175 | 0.91 | PDE5A (0.72) | PDE5APDE1APDE1BPDE1CADORA2B | |
| SCHEMBL6305289 | 0.90 | PDE5A (0.61) | PDE5AADORA2BPDE3BPDE3AADORA3 | |
| SCHEMBL6313024 | 0.89 | PDE5A (0.62) | PDE5AADORA2BPDE3BPDE3AADORA3 | |
| SCHEMBL6309364 | 0.88 | PDE5A (0.68) | PDE5APDE1APDE1BPDE1CADORA2B | |
| SCHEMBL6304667 | 0.88 | PDE5A (0.61) | PDE5AADORA2BPDE3BPDE3AADORA3 | |
| SCHEMBL4715352 | 0.87 | PDE5A (0.65) | PDE5AADORA2BPDE3BPDE3AADORA3 | |
| SCHEMBL5260190 | 0.86 | PDE5A (0.54) | PDE5APDE1APDE1BPDE1CPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6943253-B2 | 6-phenylpyrrolopyrimidinedione derivatives | ALMIRALL PRODESFARMA S.A. (ES) | 2005-09-13 | — | — | US | disclosed |
| EP-1286997-B1 | 6-PHENYLPYRROLOPYRIMIDINEDIONE DERIVATIVES | ALMIRALL PRODESFARMA SA (ES) | 2004-08-18 | — | — | EP | disclosed |
| US-20030232838-A1 | Nitrogen compounds such as 3-Methyl-6-(5-(4-methylpiperazine-1-sulphonyl)-2-propoxyphenyl)-1-propyl-1,5-dihydropyrrolo(3,2-d)pyrimidine-2,4-dione, used for prophylaxis of cardiovascular disorders | PARALLEL WIRELESS, INC. | 2003-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030232838-A1 | Nitrogen compounds such as 3-Methyl-6-(5-(4-methylpiperazine-1-sulphonyl)-2-propoxyphenyl)-1-propyl-1,5-dihydropyrrolo(3,2-d)pyrimidine-2,4-dione, used for prophylaxis of cardiovascular disorders | PDE5A, PDE2A, PDE3A | PDE5A 1/4885PDE1A 38/4885PDE1B 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.