Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.44 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.44 |
| ▸ | TERT | O14746 | 2/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4844832 | 0.88 | CD274 (0.42) | CD274PDCD1HRH4HRH3LMNA | |
| SCHEMBL3537091 | 0.82 | CD274 (0.41) | CD274PDCD1HRH4HRH3LMNA | |
| SCHEMBL4846945 | 0.78 | SCN5A (0.45) | — | |
| SCHEMBL4713265 | 0.78 | CD274 (0.42) | CD274PDCD1HRH4HRH3CHRM2 | |
| SCHEMBL4847988 | 0.77 | SCN5A (0.47) | — | |
| SCHEMBL25570588 | 0.76 | CHRM2 (0.65) | TERTCCNA2CDK2LMNACHRM2 | |
| SCHEMBL4848003 | 0.76 | CYP2C19 (0.54) | CD274LMNATSHRKDM4EHTT | |
| SCHEMBL4846025 | 0.75 | DPP7 (0.51) | CD274PDCD1SIGMAR1 | |
| Tert-Butylamine SCHEMBL3542895 | 0.75 | CD274 (0.38) | CD274PDCD1HRH4HRH3LMNA | |
| SCHEMBL3545636 | 0.74 | DPP7 (0.50) | CD274PDCD1HRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |