Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 20/20 | 0.84 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.63 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.63 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5422966 | 0.91 | ADORA2A (1.00) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL5723385 | 0.90 | ADORA2A (0.95) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL5723393 | 0.90 | ADORA2A (0.95) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL6311596 | 0.89 | ADORA2A (0.67) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL6311591 | 0.89 | ADORA2A (0.67) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL5407327 | 0.89 | ADORA2A (0.87) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL5402876 | 0.86 | ADORA2A (0.81) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL5417913 | 0.86 | ADORA2A (0.81) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL5405137 | 0.85 | ADORA2A (0.83) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL5405498 | 0.84 | ADORA2A (1.00) | ADORA2AADORA3ADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6921753-B2 | Purine derivatives | PFIZER INC (US) | 2005-07-26 | — | — | US | claimed |
| EP-1296996-B1 | PURINE DERIVATIVES | PFIZER LTD (GB) | 2004-05-26 | — | — | EP | claimed |
| US-7238676-B2 | Purine derivatives | PFIZER INC. (US) | 2007-07-03 | — | — | US | disclosed |
| US-7238676-B2 | Purine derivatives | PFIZER INC. (US) | 2007-07-03 | — | — | US | disclosed |