Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 20/20 | 0.77 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.65 |
| ▸ | TNKS | O95271 | 1/20 | 0.57 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.57 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.57 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.57 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.57 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.57 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL633901 | 0.85 | PARP1 (0.70) | PARP1PARP2TNKSPARP14PARP10 | |
| SCHEMBL630603 | 0.84 | PARP1 (1.00) | PARP1PARP2TNKSPARP14PARP10 | |
| SCHEMBL18614478 | 0.83 | PARP1 (0.77) | PARP1PARP2TNKSPARP14PARP10 | |
| SCHEMBL631716 | 0.83 | PARP1 (1.00) | PARP1PARP2TNKSPARP14PARP10 | |
| SCHEMBL631315 | 0.82 | PARP1 (0.79) | PARP1PARP2 | |
| SCHEMBL630128 | 0.81 | PARP1 (1.00) | PARP1PARP2TNKSPARP14PARP10 | |
| SCHEMBL631294 | 0.81 | PARP1 (0.73) | PARP1PARP2 | |
| SCHEMBL631127 | 0.81 | PARP1 (0.85) | PARP1PARP2TNKSPARP14PARP10 | |
| SCHEMBL630707 | 0.81 | PARP1 (0.82) | PARP1PARP2TNKSPARP14PARP10 | |
| SCHEMBL631576 | 0.81 | PARP1 (0.84) | PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2420234-A1 | 1H-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position as PARP inhibitors for use in treating cancer | Abbott Laboratories (US) | 2012-02-22 | — | — | EP | disclosed |