Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 11/20 | 0.42 |
| ▸ | ITGB2 | P05107 | 9/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 9/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6197601 | 0.96 | ITGAL (0.44) | ITGALITGB2ICAM1NOTUMAKR1C3 | |
| SCHEMBL6308942 | 0.92 | NOTUM (0.43) | ITGALITGB2ICAM1NOTUMAKR1C3 | |
| SCHEMBL6309479 | 0.90 | NOTUM (0.41) | ITGALITGB2ICAM1NOTUMAKR1C3 | |
| SCHEMBL6318224 | 0.90 | NOTUM (0.42) | ITGALITGB2ICAM1NOTUMAKR1C3 | |
| SCHEMBL6310410 | 0.90 | NOTUM (0.41) | ITGALITGB2ICAM1NOTUMAKR1C3 | |
| SCHEMBL6317373 | 0.87 | NOTUM (0.39) | ITGALITGB2ICAM1NOTUMAKR1C3 | |
| SCHEMBL6311421 | 0.86 | NOTUM (0.38) | ITGALITGB2ICAM1NOTUMAKR1C3 | |
| SCHEMBL6311393 | 0.86 | ITGAL (0.40) | ITGALITGB2ICAM1NOTUMAKR1C3 | |
| SCHEMBL6308747 | 0.86 | NOTUM (0.39) | ITGALITGB2ICAM1NOTUMAKR1C3 | |
| SCHEMBL6310958 | 0.86 | USP2 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040116518-A1 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES | 2004-06-17 | — | — | US | claimed |
| US-6867203-B2 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES (US) | 2005-03-15 | — | — | US | disclosed |
| US-20040116518-A1 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES | 2004-06-17 | — | — | US | disclosed |