Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 15/20 | 0.82 |
| ▸ | PTPRA | P18433 | 4/20 | 0.82 |
| ▸ | PTPRF | P10586 | 4/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6319527 | 0.90 | PTPN1 (1.00) | PTPN1PTPRAPTPRFMEN1POLB | |
| SCHEMBL6311384 | 0.86 | PTPN1 (1.00) | PTPN1PTPRAPTPRFMEN1POLB | |
| SCHEMBL6310883 | 0.82 | PTPN1 (1.00) | PTPN1PTPRAPTPRFMEN1POLB | |
| SCHEMBL6313036 | 0.80 | PTPN1 (0.83) | PTPN1PTPRAPTPRFMEN1POLB | |
| SCHEMBL6312262 | 0.79 | PTPN1 (1.00) | PTPN1PTPRAPTPRFMEN1POLB | |
| SCHEMBL6319544 | 0.78 | PTPN1 (1.00) | PTPN1PTPRAPTPRFMEN1POLB | |
| SCHEMBL7686981 | 0.77 | PTPN1 (0.51) | PTPN1PTPRAPTPRFMEN1POLB | |
| SCHEMBL6309785 | 0.77 | PTPN1 (1.00) | PTPN1PTPRAPTPRFMEN1POLB | |
| SCHEMBL6313049 | 0.76 | PTPN1 (0.93) | PTPN1PTPRAPTPRFMEN1POLB | |
| SCHEMBL6309704 | 0.75 | PTPN1 (1.00) | PTPN1PTPRAPTPRFMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050119332-A1 | Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases) | JEPPESEN LONE (DK) | 2005-06-02 | — | — | US | claimed |
| US-20020002199-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2002-01-03 | — | — | US | claimed |
| US-20050119332-A1 | Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases) | JEPPESEN LONE (DK) | 2005-06-02 | — | — | US | disclosed |
| US-20020165398-A1 | Modulators of protein tyrosine phosphatases (PTPases) | JEPPESEN LONE (DK) | 2002-11-07 | — | — | US | disclosed |
| US-20020002199-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2002-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020165398-A1 | Modulators of protein tyrosine phosphatases (PTPases) | PTPRCAP, PTPRS, PTPRO | PTPN1 7/4885PTPRA 5/4885PTPRF 17/4885 |
| US-20020002199-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | PTPRCAP, PTPRS, PTPRA | PTPN1 7/4885PTPRA 3/4885PTPRF 17/4885 |
| US-20050119332-A1 | Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases) | PTPRCAP, PTPRS, PTPN1 | PTPN1 3/4885PTPRA 8/4885PTPRF 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.