Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 19/20 | 0.50 |
| ▸ | ITGB2 | P05107 | 15/20 | 0.50 |
| ▸ | ICAM1 | P05362 | 15/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6308765 | 0.91 | ITGAL (0.57) | ITGALITGB2ICAM1NOTUM | |
| SCHEMBL6316947 | 0.90 | ITGAL (0.62) | ITGALITGB2ICAM1NOTUM | |
| SCHEMBL6567891 | 0.88 | ITGAL (0.57) | ITGALITGB2ICAM1 | |
| SCHEMBL6318248 | 0.88 | ITGAL (0.57) | ITGALITGB2ICAM1 | |
| SCHEMBL6311952 | 0.83 | NOTUM (0.41) | ITGALITGB2ICAM1NOTUM | |
| SCHEMBL6308954 | 0.81 | ITGAL (0.63) | ITGALITGB2ICAM1 | |
| SCHEMBL6568662 | 0.81 | ITGAL (0.63) | ITGALITGB2ICAM1 | |
| SCHEMBL6311965 | 0.81 | NOTUM (0.39) | ITGALITGB2ICAM1NOTUM | |
| SCHEMBL6312354 | 0.79 | ITGAL (0.49) | ITGALITGB2ICAM1 | |
| SCHEMBL6568044 | 0.79 | ITGAL (0.49) | ITGALITGB2ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867203-B2 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES (US) | 2005-03-15 | — | — | US | disclosed |
| US-20040116518-A1 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES | 2004-06-17 | — | — | US | disclosed |