Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.46 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313240 | 0.79 | GLA (0.52) | NPC1L3MBTL1GLATDP1MAPT | |
| SCHEMBL6313245 | 0.79 | GLA (0.52) | NPC1L3MBTL1GLATDP1MAPT | |
| SCHEMBL27560284 | 0.74 | MAPT (0.57) | NPC1GLATDP1MAPTALDH1A1 | |
| SCHEMBL13268552 | 0.73 | EGFR (0.42) | NPC1MAPTALDH1A1RECQLCYP1A2 | |
| SCHEMBL15263885 | 0.73 | EGFR (0.42) | NPC1MAPTALDH1A1RECQLCYP1A2 | |
| SCHEMBL11476908 | 0.72 | TDP1 (0.61) | NPC1L3MBTL1GLATDP1MAPT | |
| SCHEMBL11476916 | 0.72 | TDP1 (0.61) | NPC1L3MBTL1GLATDP1MAPT | |
| SCHEMBL4029202 | 0.72 | MAPT (0.64) | NPC1L3MBTL1GLATDP1MAPT | |
| SCHEMBL4023735 | 0.72 | MAPT (0.64) | NPC1L3MBTL1GLATDP1MAPT | |
| SCHEMBL6313483 | 0.71 | MAPT (0.53) | NPC1GLATDP1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6956049-B1 | Methods of modulating processes mediated by excitatory amino acid receptors | MERCK & CO., INC. (US) | 2005-10-18 | — | — | US | disclosed |
| EP-1214303-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | Merck & Co., Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001016121-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | MERCK & CO., INC. (US) | 2001-03-08 | — | — | WO | disclosed |