Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 14/20 | 0.74 |
| ▸ | EGFR | P00533 | 3/20 | 0.54 |
| ▸ | INSR | P06213 | 2/20 | 0.54 |
| ▸ | MET | P08581 | 2/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | TEK | Q02763 | 2/20 | 0.54 |
| ▸ | ALPL | P05186 | 3/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6312272 | 0.85 | IGF1R (0.65) | IGF1REGFRINSRMETCDK2 | |
| SCHEMBL6319666 | 0.82 | IGF1R (0.72) | IGF1REGFRINSRMETCDK2 | |
| SCHEMBL6311507 | 0.76 | IGF1R (0.67) | IGF1REGFRINSRMETCDK2 | |
| SCHEMBL6319818 | 0.74 | IGF1R (0.67) | IGF1REGFRINSRMETCDK2 | |
| SCHEMBL1701968 | 0.74 | IGF1R (0.60) | IGF1RALPL | |
| SCHEMBL16127523 | 0.73 | AURKA (0.68) | IGF1REGFRCDK2PLK1AURKA | |
| SCHEMBL16127509 | 0.71 | IGF1R (0.72) | IGF1REGFRCDK2PLK1AURKA | |
| SCHEMBL6320480 | 0.70 | IGF1R (0.69) | IGF1REGFRINSRMETCDK2 | |
| SCHEMBL31592519 | 0.70 | IGF1R (0.58) | IGF1REGFRINSRMETCDK2 | |
| SCHEMBL6313665 | 0.69 | IGF1R (0.82) | IGF1REGFRINSRMETCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6939874-B2 | Substituted pyrimidinyl derivatives and methods of use | AMGEN INC. (US) | 2005-09-06 | — | — | US | disclosed |