Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.37 |
| ▸ | PDCD1LG2 | Q9BQ51 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3537091 | 0.85 | CD274 (0.41) | SMN1; SMN2CD274PDCD1LG2MEN1KMT2A | |
| SCHEMBL5867470 | 0.81 | SMN1; SMN2 (0.47) | SMN1; SMN2CD274PDCD1LG2MEN1KMT2A | |
| SCHEMBL4844832 | 0.79 | CD274 (0.42) | SMN1; SMN2CD274PDCD1LG2MEN1KMT2A | |
| SCHEMBL3456835 | 0.75 | HRH3 (0.44) | SMN1; SMN2MEN1KMT2ALMNAKDM4E | |
| SCHEMBL3457044 | 0.71 | HRH3 (0.51) | SMN1; SMN2MEN1KMT2ALMNAHTT | |
| SCHEMBL3540435 | 0.70 | CD274 (0.42) | SMN1; SMN2CD274MEN1KMT2ALMNA | |
| SCHEMBL3542036 | 0.70 | MEN1 (0.39) | SMN1; SMN2MEN1KMT2ALMNAKDM4E | |
| SCHEMBL4713979 | 0.70 | SMN1; SMN2 (0.53) | SMN1; SMN2MEN1KMT2ALMNAKDM4E | |
| SCHEMBL3457092 | 0.70 | CHRM2 (0.51) | SMN1; SMN2CD274MEN1KMT2AKDM4E | |
| SCHEMBL4717200 | 0.69 | CYP1A2 (0.53) | MEN1KMT2ALMNAKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |