Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 2/20 | 0.53 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.53 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.53 |
| ▸ | TNKS | O95271 | 1/20 | 0.53 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313483 | 1.00 | MAPT (0.53) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL27560284 | 0.81 | MAPT (0.57) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL4023735 | 0.78 | MAPT (0.64) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL4029202 | 0.78 | MAPT (0.64) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL16588259 | 0.76 | HDAC1 (0.61) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL6313240 | 0.75 | GLA (0.52) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL6313245 | 0.75 | GLA (0.52) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL29111191 | 0.75 | MAPT (0.59) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL11476908 | 0.75 | TDP1 (0.61) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL11476916 | 0.75 | TDP1 (0.61) | MAPTHDAC3HDAC4HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6956049-B1 | Methods of modulating processes mediated by excitatory amino acid receptors | MERCK & CO., INC. (US) | 2005-10-18 | — | — | US | disclosed |
| EP-1214303-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | Merck & Co., Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001016121-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | MERCK & CO., INC. (US) | 2001-03-08 | — | — | WO | disclosed |