Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ITGB1 | P05556 | 5/20 | 0.46 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.46 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.45 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ITGAV | P06756 | 1/20 | 0.41 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL630024 | 1.00 | POLB (0.54) | POLBITGB1ITGA5ITGA4KCNQ1 | |
| SCHEMBL1381295 | 1.00 | POLB (0.54) | POLBITGB1ITGA5ITGA4KCNQ1 | |
| SCHEMBL1380078 | 0.94 | POLB (0.53) | POLBITGB1ITGA5ITGA4KCNQ1 | |
| SCHEMBL630103 | 0.94 | POLB (0.53) | POLBITGB1ITGA5ITGA4KCNQ1 | |
| SCHEMBL630210 | 0.92 | KCNQ1 (0.54) | POLBITGB1ITGA5ITGA4KCNQ1 | |
| SCHEMBL13206964 | 0.92 | POLB (0.51) | POLBITGB1ITGA5ITGA4KCNQ1 | |
| SCHEMBL631058 | 0.92 | POLB (0.51) | POLBITGB1ITGA5ITGA4KCNQ1 | |
| SCHEMBL1383068 | 0.92 | POLB (0.51) | POLBITGB1ITGA5ITGA4KCNQ1 | |
| SCHEMBL1382352 | 0.91 | POLB (0.51) | POLBITGB1ITGA5ITGA4KCNQ1 | |
| SCHEMBL630495 | 0.90 | POLB (0.44) | POLBKCNQ1ALDH1A1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778637-B1 | FKBP-binding composition and pharmaceutical use thereof | AVENTIS PHARMA INC (US) | 2012-02-22 | — | — | EP | disclosed |