Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28055983 | 0.77 | — | — | |
| SCHEMBL4263709 | 0.76 | — | — | |
| SCHEMBL14678179 | 0.76 | HSP90AA1 (0.40) | HSP90AA1CYP19A1P2RX7 | |
| SCHEMBL7703784 | 0.76 | HSP90AA1 (0.35) | HSP90AA1CYP19A1 | |
| SCHEMBL1525815 | 0.73 | SLC6A2 (0.45) | — | |
| SCHEMBL29724050 | 0.73 | SLC6A2 (0.45) | — | |
| SCHEMBL31291331 | 0.72 | — | — | |
| SCHEMBL29857995 | 0.72 | — | — | |
| SCHEMBL644984 | 0.72 | — | — | |
| SCHEMBL7349683 | 0.70 | CYP3A4 (0.41) | CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2322518-B1 | Method of manufacture of 1,3-dioxolane and 1,3-oxathiolane nucleosides | GILEAD SCIENCES INC (US) | 2015-02-25 | — | — | EP | claimed |
| US-6939965-B2 | Process of manufacture of 1,3-oxathiolane nucleosides using titanium trichloride mono-isopropoxide | GILEAD SCIENCES, INC. (US) | 2005-09-06 | — | — | US | claimed |
| US-6518425-B1 | A process for producing a 1,3-oxathiolane nucleoside comprising reacting a 5-halo-2-protected-oxymethyl-1,3-oxathiolane with a silylated purine or pyrimidine without the addition of a Lewis acid or an additional base to the reaction | EMORY UNIVERSITY | 2003-02-11 | — | — | US | claimed |
| EP-2322518-B1 | Method of manufacture of 1,3-dioxolane and 1,3-oxathiolane nucleosides | GILEAD SCIENCES INC (US) | 2015-02-25 | — | — | EP | disclosed |