Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hexadecyl Dihydrogen Phosphate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR3 | Q9UBY5 | 12/20 | 0.72 |
| ▸ | LPAR2 | Q9HBW0 | 9/20 | 0.72 |
| ▸ | LPAR1 | Q92633 | 7/20 | 0.72 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.47 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.47 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.47 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid Monododecyl Ester SCHEMBL1882508 | 1.00 | LPAR3 (0.72) | LPAR3LPAR2LPAR1LPAR5S1PR2 | |
| Diethanolamine SCHEMBL27863592 | 1.00 | LPAR3 (0.72) | LPAR3LPAR2LPAR1LPAR5S1PR2 | |
| Diethanolamine SCHEMBL11424123 | 1.00 | LPAR3 (0.72) | LPAR3LPAR2LPAR1LPAR5S1PR2 | |
| Phosphoric Acid Monotetradecyl Ester SCHEMBL28891633 | 1.00 | LPAR3 (0.72) | LPAR3LPAR2LPAR1LPAR5S1PR2 | |
| Diethanolamine SCHEMBL31042095 | 1.00 | LPAR3 (0.72) | LPAR3LPAR2LPAR1LPAR5S1PR2 | |
| Hexadecyl Dihydrogen Phosphate SCHEMBL9365294 | 1.00 | LPAR3 (0.72) | LPAR3LPAR2LPAR1LPAR5S1PR2 | |
| Hexadecyl Dihydrogen Phosphate SCHEMBL28236129 | 1.00 | LPAR3 (0.72) | LPAR3LPAR2LPAR1LPAR5S1PR2 | |
| Phosphoric Acid Monododecyl Ester SCHEMBL29070679 | 0.98 | LPAR3 (0.70) | LPAR3LPAR2LPAR1LPAR5S1PR2 | |
| Diethanolamine SCHEMBL3471215 | 0.91 | LPAR3 (0.72) | LPAR3LPAR2LPAR1ENPP2 | |
| Hexadecyl Dihydrogen Phosphate SCHEMBL29103357 | 0.91 | LPAR3 (0.60) | LPAR3LPAR2LPAR1LPAR5S1PR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3376 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12576108-B2 | Compositions comprising hyper harmonized hydroxyl modified fullerene substances | FIELDPOINT (CYPRUS) LIMITED (CY) | 2026-03-17 | — | — | US | claimed |
| US-20250277207-A1 | One or Multiple-Steps Extraction of Nucleic Acids and other Biomolecules using a Cloudy Precipitated Solution | CHHALLIYIL PRADHEEP (US) | 2025-09-04 | — | — | US | claimed |
| US-20250049771-A1 | METHOD FOR REDUCING SIDE EFFECTS FROM ADMINISTRATION OF PHOSPHODIESTERASE-4 INHIBITORS | ARCUTIS BIOTHERAPEUTICS, INC. (US) | 2025-02-13 | — | — | US | claimed |
| WO-2025021320-A1 | RETINOL CONTAINING DAY CREAM | THE BOOTS COMPANY PLC (GB) | 2025-01-30 | — | — | WO | claimed |
| US-20240382504-A1 | TREATMENT OF SKIN CONDITIONS USING HIGH KRAFFT TEMPERATURE ANIONIC SURFACTANTS | ARCUTIS BIOTHERAPEUTICS, INC. (US) | 2024-11-21 | — | — | US | claimed |
| US-20240350378-A1 | DEODORANT COSMETIC PRODUCT | JOBAN BEAUTY, INC. (US) | 2024-10-24 | — | — | US | claimed |
| US-12042487-B2 | Method for reducing side effects from administration of phosphodiesterase-4 inhibitors | ARCUTIS BIOTHERAPEUTICS, INC. (US) | 2024-07-23 | — | — | US | claimed |
| EP-3765088-B1 | TRANSDERMAL AND/OR DERMAL DELIVERY OF LIPOPHILIC ACTIVE AGENTS | POVIVA CORP (US) | 2024-03-20 | — | — | EP | claimed |
| CN-113365599-B | Composition for stabilizing vitamin C derivatives by gel structure | 株式会社爱茉莉太平洋 | 2024-03-15 | — | — | CN | claimed |
| US-20240024300-A1 | METHOD FOR REDUCING SIDE EFFECTS FROM ADMINISTRATION OF PHOSPHODIESTERASE-4 INHIBITORS | ARCUTIS BIOTHERAPEUTICS, INC. (US) | 2024-01-25 | — | — | US | claimed |
| US-5116604-A | Sunscreen compositions containing novel neopentanoate esters | BERNEL CHEMICAL CO. (US) | 1992-05-26 | — | — | US | claimed |
| EP-0443007-A1 | AN EXTERNAL ANALGESIC LOTION AND METHOD OF MAKING. | IVY JEFFERY W (US) | 1991-08-28 | — | — | EP | claimed |
| US-5013726-A | External analgesic lotion containing active ingredients of methyl salicylate and camphor and menthol and method of making such lotion | AU PHARMACEUTICALS, INC. | 1991-05-07 | — | — | US | claimed |
| WO-1991004010-A1 | AN EXTERNAL ANALGESIC LOTION AND METHOD OF MAKING | IVY JEFFERY W (US) | 1991-04-04 | — | — | WO | claimed |
| EP-0404331-A2 | Cosmetic composition | UNILEVER PLC (GB) | 1990-12-27 | — | — | EP | claimed |
| US-4970216-A | CONTAINING FREE RADICAL INHIBITOR OR DEACTIVATOR | RICHARDSON VICKS, INC. (US) | 1990-11-13 | — | — | US | claimed |
| US-4939179-A | Cosmetic emulsions with hydrocarbon thickening agents | CHESEBROUGH-POND'S INC. (US) | 1990-07-03 | — | — | US | claimed |
| US-4847267-A | 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID AND ETHOXYQUIN | CHARLES OF THE RITZ GROUP LTD. (US) | 1989-07-11 | — | — | US | claimed |
| EP-0238302-A1 | Skin treatment composition | Richardson-Vicks, Inc. (US) | 1987-09-23 | — | — | EP | claimed |
| US-4481186-A | SKIN CONDITIONERS | CHARLES OF THE RITZ GROUP LTD. (US) | 1984-11-06 | — | — | US | claimed |