SCHEMBL6316970

SCHEMBL6316970

CCCC(Cc1ccccc1)NC=O

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 1/20 0.73
MEN1 O00255 2/20 0.59
KMT2A Q03164 2/20 0.59
TAAR1 Q96RJ0 1/20 0.59
SIGMAR1 Q99720 3/20 0.53
SLC6A4 P31645 1/20 0.50
HDAC3 O15379 1/20 0.42
HDAC4 P56524 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC2 Q92769 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
CTSK P43235 4/20 0.42
CTSL P07711 1/20 0.41
CTSB P07858 1/20 0.41
CTSH P09668 1/20 0.41
POLB P06746 1/20 0.41
ADH1B P00325 1/20 0.40
ADH1C P00326 1/20 0.40
ADH1A P07327 1/20 0.40
ADH7 P40394 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11706976 0.90 EPHX1 (0.69) EPHX1MEN1KMT2ATAAR1SIGMAR1
SCHEMBL7509446 0.86 EPHX1 (0.79) EPHX1MEN1KMT2ATAAR1SIGMAR1
SCHEMBL29257172 0.85 EPHX1 (1.00) EPHX1MEN1KMT2ATAAR1SIGMAR1
SCHEMBL13970520 0.83 EPHX1 (0.69) EPHX1MEN1KMT2ATAAR1SIGMAR1
SCHEMBL11133431 0.82 EPHX1 (0.53) EPHX1MEN1KMT2ATAAR1SIGMAR1
SCHEMBL3124199 0.82 EPHX1 (0.67) EPHX1MEN1KMT2ATAAR1SIGMAR1
SCHEMBL15537367 0.81 EPHX1 (0.49) EPHX1
SCHEMBL2703617 0.79 EPHX1 (0.79) EPHX1MEN1KMT2ATAAR1SLC6A4
SCHEMBL3964533 0.79 EPHX1 (0.79) EPHX1MEN1KMT2ATAAR1SLC6A4
SCHEMBL10433409 0.79 EPHX1 (0.79) EPHX1MEN1KMT2ATAAR1SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1501830-A1 7-ARYL-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES Actelion Pharmaceuticals Ltd. (CH) 2005-02-02 EP disclosed
WO-2003093267-A1 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES ACTELION PHARMACEUTICALS LTD (CH) 2003-11-13 WO disclosed