Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 18/20 | 0.70 |
| ▸ | ITGB2 | P05107 | 16/20 | 0.70 |
| ▸ | ICAM1 | P05362 | 16/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6198270 | 0.92 | ITGAL (0.66) | ITGALITGB2ICAM1KMT2AKDM4E | |
| SCHEMBL6196883 | 0.89 | ITGB2 (0.56) | ITGALITGB2ICAM1KMT2AKDM4E | |
| SCHEMBL6199010 | 0.89 | ITGAL (0.64) | ITGALITGB2ICAM1KMT2A | |
| SCHEMBL6199611 | 0.83 | ITGB2 (0.52) | ITGALITGB2ICAM1KDM4ELMNA | |
| SCHEMBL6317425 | 0.82 | ITGAL (1.00) | ITGALITGB2ICAM1 | |
| SCHEMBL6308508 | 0.82 | ITGAL (0.55) | ITGALITGB2ICAM1MAPT | |
| SCHEMBL6199576 | 0.81 | ITGAL (0.61) | ITGALITGB2ICAM1 | |
| SCHEMBL6199026 | 0.80 | ITGAL (0.52) | ITGALITGB2ICAM1KMT2A | |
| SCHEMBL6199566 | 0.78 | ITGAL (0.51) | ITGALITGB2ICAM1MAPT | |
| SCHEMBL6197126 | 0.77 | ITGAL (0.50) | ITGALITGB2ICAM1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878700-B1 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES (US) | 2005-04-12 | — | — | US | claimed |
| US-6878700-B1 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES (US) | 2005-04-12 | — | — | US | disclosed |
| US-6867203-B2 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES (US) | 2005-03-15 | — | — | US | disclosed |
| US-20040116518-A1 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES | 2004-06-17 | — | — | US | disclosed |