Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 18/20 | 0.69 |
| ▸ | ITGB2 | P05107 | 15/20 | 0.69 |
| ▸ | ICAM1 | P05362 | 15/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6199452 | 0.93 | ITGAL (0.68) | ITGALITGB2ICAM1KDM4E | |
| SCHEMBL6196886 | 0.90 | KDM4E (0.56) | ITGALITGB2ICAM1KDM4ENPC1 | |
| SCHEMBL6200934 | 0.90 | ITGAL (0.66) | ITGALITGB2ICAM1KDM4ENPC1 | |
| SCHEMBL7857946 | 0.83 | ITGB2 (0.45) | ITGALITGB2ICAM1KDM4E | |
| SCHEMBL6199614 | 0.83 | ITGB2 (0.45) | ITGALITGB2ICAM1KDM4E | |
| SCHEMBL6308513 | 0.83 | ITGAL (0.55) | ITGALITGB2ICAM1KDM4ENPC1 | |
| SCHEMBL6317425 | 0.82 | ITGAL (1.00) | ITGALITGB2ICAM1 | |
| SCHEMBL6245735 | 0.81 | ITGAL (0.57) | ITGALITGB2ICAM1KDM4ENPC1 | |
| SCHEMBL6199028 | 0.81 | ITGAL (0.56) | ITGALITGB2ICAM1KDM4ENPC1 | |
| SCHEMBL6200450 | 0.81 | ITGAL (0.78) | ITGALITGB2ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878700-B1 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES (US) | 2005-04-12 | — | — | US | claimed |
| US-6878700-B1 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES (US) | 2005-04-12 | — | — | US | disclosed |
| US-6867203-B2 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES (US) | 2005-03-15 | — | — | US | disclosed |
| US-20040116518-A1 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES | 2004-06-17 | — | — | US | disclosed |