Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.70 |
| ▸ | JAK3 | P52333 | 18/20 | 0.70 |
| ▸ | JAK1 | P23458 | 17/20 | 0.70 |
| ▸ | TYK2 | P29597 | 5/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL566848 | 1.00 | JAK2 (0.70) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL567332 | 1.00 | JAK2 (0.70) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL10099380 | 0.92 | JAK2 (0.68) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL10099457 | 0.89 | JAK2 (0.71) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL10099364 | 0.87 | JAK3 (0.70) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL10099448 | 0.86 | JAK2 (0.60) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL10099406 | 0.85 | JAK3 (0.74) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL565647 | 0.85 | JAK2 (0.69) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL10099365 | 0.85 | JAK2 (0.69) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL10099366 | 0.85 | JAK3 (0.69) | JAK2JAK3JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2420502-A1 | FUSED PYRROLOPYRIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2012-02-22 | — | — | EP | disclosed |