Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 3/20 | 1.00 |
| ▸ | PDE2A | O00408 | 2/20 | 0.55 |
| ▸ | PDE5A | O76074 | 2/20 | 0.51 |
| ▸ | YTHDC1 | Q96MU7 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6317366 | 0.92 | PDE3B (0.86) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6324594 | 0.90 | PDE3B (0.81) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6318240 | 0.89 | PDE3B (0.80) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6322999 | 0.89 | PDE3B (0.80) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6319661 | 0.88 | PDE3B (0.79) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6317786 | 0.88 | PDE3B (0.78) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6325129 | 0.87 | PDE3B (0.77) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6317823 | 0.87 | PDE3B (0.76) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6318575 | 0.86 | PDE3B (0.75) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6322830 | 0.86 | PDE3B (0.75) | PDE3BPDE3APDE2APDE5AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6838559-B2 | Purine inhibitors of phosphodiesterase (PDE) 7 | BRISTOL-MYERS SQUIBB CO. (US) | 2005-01-04 | — | — | US | claimed |
| US-20030104974-A1 | Dual inhibitorsof PDE 7 and PDE 4 | BRISTOL-MYERS SQUIBB COMPANY | 2003-06-05 | — | — | US | disclosed |
| US-20030100571-A1 | Purine inhibitors of phosphodiesterase (PDE) | BRISTOL-MYERS SQUIBB COMPANY | 2003-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030100571-A1 | Purine inhibitors of phosphodiesterase (PDE) | PDE7A, PDE7B, PDE3A | PDE3B 5/4885PDE3A 3/4885PDE2A 4/4885 |
| US-20030104974-A1 | Dual inhibitorsof PDE 7 and PDE 4 | PDE4A, PDE4B, PDE7B | PDE3B 10/4885PDE3A 13/4885PDE2A 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.