Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.62 |
| ▸ | PDE2A | O00408 | 2/20 | 0.62 |
| ▸ | PDE5A | O76074 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | DHODH | Q02127 | 5/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6319070 | 0.94 | PDE3B (0.62) | PDE3BPDE3APDE2APDE5AMAPT | |
| SCHEMBL6317718 | 0.91 | PDE3B (0.67) | PDE3BPDE3APDE2APDE5AMAPT | |
| SCHEMBL6325720 | 0.90 | PDE3B (0.59) | PDE3BPDE3APDE2APDE5AMAPT | |
| SCHEMBL6323728 | 0.90 | PDE3B (0.59) | PDE3BPDE3APDE2APDE5AMAPT | |
| SCHEMBL6316078 | 0.87 | PDE3B (0.66) | PDE3BPDE3APDE2APDE5AMAPT | |
| SCHEMBL6319457 | 0.86 | PDE3B (0.58) | PDE3BPDE3APDE2APDE5AMAPT | |
| SCHEMBL6319303 | 0.77 | PDE3B (1.00) | PDE3BPDE3APDE2APDE5AMAPT | |
| SCHEMBL6323438 | 0.76 | PDE3B (0.90) | PDE3BPDE3APDE2APDE5AMAPT | |
| SCHEMBL6325377 | 0.76 | PDE3B (0.84) | PDE3BPDE3APDE2APDE5AMAPT | |
| SCHEMBL6317793 | 0.75 | PDE3B (0.78) | PDE3BPDE3APDE2APDE5AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6838559-B2 | Purine inhibitors of phosphodiesterase (PDE) 7 | BRISTOL-MYERS SQUIBB CO. (US) | 2005-01-04 | — | — | US | claimed |
| EP-1501830-A1 | 7-ARYL-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | Actelion Pharmaceuticals Ltd. (CH) | 2005-02-02 | — | — | EP | disclosed |
| US-6838559-B2 | Purine inhibitors of phosphodiesterase (PDE) 7 | BRISTOL-MYERS SQUIBB CO. (US) | 2005-01-04 | — | — | US | disclosed |
| WO-2003093267-A1 | 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-11-13 | — | — | WO | disclosed |