Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.63 |
| ▸ | INSR | P06213 | 4/20 | 0.63 |
| ▸ | TEK | Q02763 | 4/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.63 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.63 |
| ▸ | CSF1R | P07333 | 2/20 | 0.63 |
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 5/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6397207 | 0.90 | KDR (0.51) | KDRINSRTEKPDGFRBPDGFRA | |
| SCHEMBL6313512 | 0.90 | KDR (0.51) | KDRINSRTEKPDGFRBPDGFRA | |
| SCHEMBL6313522 | 0.90 | KDR (0.51) | KDRINSRTEKPDGFRBPDGFRA | |
| SCHEMBL28121258 | 0.78 | KDR (0.48) | KDRINSRTEKPDGFRBPDGFRA | |
| SCHEMBL6401617 | 0.78 | CFTR (0.49) | KDRINSRTEKPDGFRBPDGFRA | |
| SCHEMBL6321943 | 0.78 | CFTR (0.49) | KDRINSRTEKPDGFRBPDGFRA | |
| SCHEMBL6321949 | 0.78 | CFTR (0.49) | KDRINSRTEKPDGFRBPDGFRA | |
| SCHEMBL6393446 | 0.78 | KDR (1.00) | KDRINSRTEKPDGFRBPDGFRA | |
| SCHEMBL6394114 | 0.76 | KDR (0.57) | KDRINSRTEKPDGFRBPDGFRA | |
| SCHEMBL6399896 | 0.76 | KDR (0.57) | KDRINSRTEKPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549645-A1 | 4,6-DIAMINOSUBSTITUTED-2-[OXY OR AMINOXY]-[1,3,5]TRIAZINES AS PROTEIN TYROSINE KINASE INHIBITORS | Johnson & Johnson Pharmaceutical Research & Development, Inc. (US) | 2005-07-06 | — | — | EP | claimed |
| WO-2004031184-A1 | 4,6-DIAMINOSUBSTITUTED-2-[OXY OR AMINOXY]-[1,3,5]TRIAZINES AS PROTEIN TYROSINE KINASE INHIBITORS | JOHNSON & JOHNSON PHARMACEUTICAL RESEARCH & DEVELOPMENT, INC. (US) | 2004-04-15 | — | — | WO | claimed |