Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.52 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.52 |
| ▸ | AHR | P35869 | 2/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.51 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.49 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.41 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.41 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10945814 | 0.83 | PIK3CD (0.75) | ASH1LPIK3CDPIK3CBAHRPIK3CG | |
| SCHEMBL6322061 | 0.82 | PIK3CD (0.64) | ASH1LPIK3CDPIK3CBAHRPIK3CG | |
| SCHEMBL6321711 | 0.81 | ASH1L (0.60) | ASH1LPIK3CDPIK3CBAHRPIK3CG | |
| SCHEMBL29712113 | 0.80 | PIK3CD (0.70) | ASH1LPIK3CDPIK3CBAHRPIK3CG | |
| SCHEMBL2193011 | 0.80 | PIK3CD (0.70) | ASH1LPIK3CDPIK3CBAHRPIK3CG | |
| SCHEMBL23259083 | 0.79 | ASH1L (0.59) | ASH1LPIK3CDPIK3CBAHRPIK3CG | |
| SCHEMBL6321811 | 0.79 | CSNK2B (0.62) | ASH1LPIK3CDPIK3CBAHRPIK3CG | |
| SCHEMBL6322388 | 0.79 | ASH1L (0.59) | ASH1LPIK3CDPIK3CBAHRPIK3CG | |
| SCHEMBL982028 | 0.79 | ASH1L (0.63) | ASH1LPIK3CDPIK3CBAHRPIK3CG | |
| SCHEMBL1129041 | 0.78 | PIK3CD (0.51) | ASH1LPIK3CDPIK3CBAHRPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861418-B2 | 4-aryl substituted indolinones | SUGEN, INC. (US) | 2005-03-01 | — | — | US | disclosed |
| US-20040157909-A1 | 4-Aryl substituted indolinones | SUGEN, INC. | 2004-08-12 | — | — | US | disclosed |
| US-6677368-B2 | 4-aryl substituted indolinones | SUGEN, INC. | 2004-01-13 | — | — | US | disclosed |
| EP-1349852-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | Sugen, Inc. (US) | 2003-10-08 | — | — | EP | disclosed |
| US-20030069297-A1 | 4-aryl substituted indolinones | SUGEN, INC. | 2003-04-10 | — | — | US | disclosed |
| WO-2002055517-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | CUI JINGRONG (US) | 2002-07-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069297-A1 | 4-aryl substituted indolinones | CDK5, CAMK4, TNK2 | ASH1L 1883/4885PIK3CD 365/4885PIK3CB 275/4885 |
| US-20040157909-A1 | 4-Aryl substituted indolinones | CDK5, CAMK4, TNK2 | ASH1L 1883/4885PIK3CD 365/4885PIK3CB 275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.