Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 13/20 | 0.41 |
| ▸ | MC5R | P33032 | 6/20 | 0.41 |
| ▸ | MC3R | P41968 | 5/20 | 0.41 |
| ▸ | MC1R | Q01726 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4697707 | 0.91 | MC4R (0.40) | MC4RMC5RMC3RMC1RKMT2A | |
| SCHEMBL6322063 | 0.88 | MC4R (0.41) | MC4RMC5RMC3RMC1RMAPK1 | |
| SCHEMBL6739213 | 0.87 | MAPK1 (0.47) | MC4RMC5RMC3RMC1RMAPK1 | |
| SCHEMBL4701498 | 0.86 | MC4R (0.46) | MC4RMC5RMC3RMC1RMAPK1 | |
| SCHEMBL4700300 | 0.85 | KMT2A (0.49) | MC4RMC5RMC3RMC1RMAPK1 | |
| SCHEMBL4698437 | 0.85 | MC4R (0.44) | MC4RMC5RMC3RMC1RMAPK1 | |
| SCHEMBL4704216 | 0.85 | MAPK1 (0.45) | MC4RMC5RMC3RMC1RMAPK1 | |
| SCHEMBL4704215 | 0.85 | MC4R (0.44) | MC4RMC5RMC3RMC1RMAPK1 | |
| SCHEMBL4699880 | 0.84 | MAPK1 (0.44) | MC4RMC5RMC3RMC1RMAPK1 | |
| SCHEMBL4701927 | 0.83 | MC4R (0.43) | MC4RMC5RMC3RMC1RMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6977264-B2 | Substituted piperidines and methods of use | AMGEN INC. (US) | 2005-12-20 | — | — | US | disclosed |