Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 3/20 | 0.53 |
| ▸ | CETP | P11597 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | TSPO | P30536 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL632509 | 0.89 | TAAR1 (0.41) | QPCTCETPTAAR1SLC6A4 | |
| SCHEMBL631672 | 0.85 | TAAR1 (0.41) | QPCTCETPTAAR1SMN1; SMN2KMT2A | |
| SCHEMBL632954 | 0.83 | TAAR1 (0.41) | QPCTCETPTAAR1SLC6A4 | |
| SCHEMBL631727 | 0.80 | TAAR1 (0.57) | TAAR1 | |
| SCHEMBL632302 | 0.80 | HDAC6 (0.47) | TAAR1EGFR | |
| SCHEMBL14189358 | 0.78 | TAAR1 (0.66) | QPCTTAAR1 | |
| SCHEMBL631532 | 0.76 | TAAR1 (0.39) | TAAR1SLC6A4 | |
| SCHEMBL2103486 | 0.74 | FGFR1 (0.50) | TAAR1 | |
| SCHEMBL224560 | 0.73 | TAAR1 (0.51) | TAAR1 | |
| SCHEMBL632904 | 0.72 | TAAR1 (0.37) | CETPTAAR1SLC6A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076497-B1 | AMINOMETHYL-4-IMIDAZOLES | HOFFMANN LA ROCHE (CH) | 2012-02-22 | — | — | EP | disclosed |
| EP-2076497-A1 | AMINOMETHYL-4-IMIDAZOLES | F. Hoffmann-Roche AG (CH) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008046757-A1 | AMINOMETHYL-4-IMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |