Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.72 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.72 |
| ▸ | PDE2A | O00408 | 2/20 | 0.72 |
| ▸ | PDE5A | O76074 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6317793 | 0.86 | PDE3B (0.78) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6318287 | 0.86 | PDE3B (0.79) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6320322 | 0.86 | PDE3B (0.72) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6317562 | 0.85 | PDE3B (0.78) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6317123 | 0.85 | PDE3B (0.78) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6317075 | 0.85 | PDE3B (0.77) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6318607 | 0.85 | PDE3B (0.87) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6319496 | 0.84 | PDE3B (0.78) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6319303 | 0.84 | PDE3B (1.00) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6325925 | 0.84 | PDE3B (1.00) | PDE3BPDE3APDE2APDE5AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6838559-B2 | Purine inhibitors of phosphodiesterase (PDE) 7 | BRISTOL-MYERS SQUIBB CO. (US) | 2005-01-04 | — | — | US | claimed |
| US-6838559-B2 | Purine inhibitors of phosphodiesterase (PDE) 7 | BRISTOL-MYERS SQUIBB CO. (US) | 2005-01-04 | — | — | US | disclosed |