Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6324738 | 0.96 | HPGD (0.47) | TSHRSMN1; SMN2HPGDCYP1A2CYP3A4 | |
| SCHEMBL6325780 | 0.89 | HPGD (0.47) | TSHRSMN1; SMN2HPGDCYP1A2CYP3A4 | |
| SCHEMBL6325850 | 0.89 | HDAC1 (0.51) | TSHRSMN1; SMN2HPGDCYP1A2CYP3A4 | |
| SCHEMBL6328500 | 0.89 | GAA (0.54) | TSHRSMN1; SMN2HPGDCYP1A2CYP3A4 | |
| SCHEMBL6332642 | 0.87 | GAA (0.54) | TSHRSMN1; SMN2HPGDCYP1A2CYP3A4 | |
| SCHEMBL6332518 | 0.87 | HDAC1 (0.51) | TSHRSMN1; SMN2HPGDCYP1A2CYP3A4 | |
| SCHEMBL6332801 | 0.87 | HPGD (0.53) | TSHRSMN1; SMN2HPGDCYP1A2CYP3A4 | |
| SCHEMBL6326087 | 0.87 | TSHR (0.51) | TSHRSMN1; SMN2HPGDCYP1A2CYP3A4 | |
| SCHEMBL6328068 | 0.86 | HDAC1 (0.51) | TSHRSMN1; SMN2HPGDCYP1A2CYP3A4 | |
| SCHEMBL6328158 | 0.85 | HPGD (0.53) | TSHRSMN1; SMN2HPGDCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924284-B2 | PARP inhibitors | ICOS CORPORATION (US) | 2005-08-02 | — | — | US | disclosed |
| US-20050065178-A1 | Substituted diazabicycloakane derivatives | ABBOTT LABORATORIES | 2005-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065178-A1 | Substituted diazabicycloakane derivatives | CHRNA7, CHRNA1, CHRNA5 | TSHR 696/4885SMN1; SMN2 826/4885HPGD 2405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.