Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6326107 | 1.00 | KMT2A (0.52) | KMT2ATSHRALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL6322209 | 0.93 | KMT2A (0.44) | KMT2ATSHRALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL6322220 | 0.93 | KMT2A (0.44) | KMT2ATSHRALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL6318712 | 0.92 | KMT2A (0.49) | KMT2ATSHRALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL6319412 | 0.92 | KMT2A (0.49) | KMT2ATSHRALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL6327523 | 0.90 | KMT2A (0.48) | KMT2ATSHRALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL6327526 | 0.90 | KMT2A (0.48) | KMT2ATSHRALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL6318824 | 0.90 | KMT2A (0.45) | KMT2ATSHRALDH1A1GAAMEN1 | |
| SCHEMBL6320845 | 0.90 | KMT2A (0.45) | KMT2ATSHRALDH1A1GAAMEN1 | |
| SCHEMBL6319353 | 0.90 | KMT2A (0.43) | KMT2ATSHRALDH1A1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6855710-B2 | Substituted indolines with an inhibitory effect on various kinases and complexes of CDKs | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-02-15 | — | — | US | disclosed |
| EP-1115704-B1 | NOVEL SUBSTITUTED INDOLINONES WITH AN INHIBITORY EFFECT ON VARIOUS KINASES AND CYCLIN/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-06-18 | — | — | EP | disclosed |