Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 15/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.57 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.57 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.57 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.57 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.57 |
| ▸ | PGR | P06401 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | RXRA | P19793 | 1/20 | 0.57 |
| ▸ | CCKAR | P32238 | 1/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10679732 | 1.00 | HMGCR (0.57) | HMGCRCYP2C9SIRT6TBXA2RADRA1A | |
| SCHEMBL27635670 | 1.00 | HMGCR (0.57) | HMGCRCYP2C9SIRT6TBXA2RADRA1A | |
| SCHEMBL6241912 | 1.00 | HMGCR (0.57) | HMGCRCYP2C9SIRT6TBXA2RADRA1A | |
| SCHEMBL10693357 | 0.89 | HMGCR (0.46) | HMGCRCYP2C9SIRT6TBXA2RADRA1A | |
| SCHEMBL10696887 | 0.89 | HMGCR (0.47) | HMGCRCYP2C9SIRT6TBXA2RADRA1A | |
| SCHEMBL10335170 | 0.83 | HMGCR (0.53) | HMGCRCYP2C9SIRT6TBXA2RADRA1A | |
| SCHEMBL10335169 | 0.83 | HMGCR (0.53) | HMGCRCYP2C9SIRT6TBXA2RADRA1A | |
| SCHEMBL9753238 | 0.80 | HMGCR (0.54) | HMGCRCYP2C9SIRT6TBXA2RADRA1A | |
| SCHEMBL10696309 | 0.80 | HMGCR (0.39) | HMGCRCYP2C9SIRT6TBXA2RADRA1A | |
| SCHEMBL10637646 | 0.77 | HMGCR (0.85) | HMGCRCYP2C9SIRT6TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050239884-A1 | Compositions comprising hmg-coa reductase inhibitor | MEYER ANDREAS | 2005-10-27 | — | — | US | disclosed |
| EP-0547000-B1 | Stabilized pharmaceutical compositions comprising an HMG-CoA reductase inhibitor compound | NOVARTIS AG (CH) | 2000-02-02 | — | — | EP | disclosed |
| US-5356896-A | Alkaline stabiling medium | SANDOZ LTD. (CH) | 1994-10-18 | — | — | US | disclosed |
| EP-0547000-A1 | Stabilized pharmaceutical compositions comprising an HMG-CoA reductase inhibitor compound | SANDOZ LTD. (CH) | 1993-06-16 | — | — | EP | disclosed |