Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 11/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.48 |
| ▸ | KDR | P35968 | 10/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.42 |
| ▸ | FLT3 | P36888 | 3/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | FLT1 | P17948 | 2/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.42 |
| ▸ | STK3 | Q13188 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.42 |
| ▸ | FLT4 | P35916 | 2/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.42 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.42 |
| ▸ | LATS1 | O95835 | 1/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.42 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6323543 | 0.89 | KDR (0.46) | PDGFRBFGFR1KDRPRKAA1FLT3 | |
| SCHEMBL6321745 | 0.85 | KDR (0.59) | PDGFRBFGFR1KDRPRKAA1FLT3 | |
| SCHEMBL6323841 | 0.84 | PDGFRB (0.57) | PDGFRBFGFR1KDRPRKAA1FLT3 | |
| SCHEMBL6327103 | 0.82 | KDR (0.58) | PDGFRBFGFR1KDRPRKAA1FLT3 | |
| SCHEMBL6327771 | 0.82 | KDR (0.44) | PDGFRBFGFR1KDRPRKAA1FLT3 | |
| SCHEMBL5830274 | 0.78 | KDR (0.56) | PDGFRBFGFR1KDRPRKAA1FLT3 | |
| SCHEMBL5830271 | 0.78 | KDR (0.56) | PDGFRBFGFR1KDRPRKAA1FLT3 | |
| SCHEMBL6319633 | 0.76 | KDR (0.52) | PDGFRBFGFR1KDRPRKAA1FLT3 | |
| SCHEMBL6319478 | 0.76 | KDR (0.43) | PDGFRBFGFR1KDRPRKAA1FLT3 | |
| SCHEMBL6322405 | 0.76 | KDR (0.42) | PDGFRBFGFR1KDRPRKAA1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861418-B2 | 4-aryl substituted indolinones | SUGEN, INC. (US) | 2005-03-01 | — | — | US | disclosed |
| US-6677368-B2 | 4-aryl substituted indolinones | SUGEN, INC. | 2004-01-13 | — | — | US | disclosed |
| EP-1349852-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | Sugen, Inc. (US) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002055517-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | CUI JINGRONG (US) | 2002-07-18 | — | — | WO | disclosed |