Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 2/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.61 |
| ▸ | KDR | P35968 | 10/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.61 |
| ▸ | EGFR | P00533 | 4/20 | 0.61 |
| ▸ | AURKA | O14965 | 6/20 | 0.59 |
| ▸ | AKT2 | P31751 | 1/20 | 0.57 |
| ▸ | RET | P07949 | 3/20 | 0.56 |
| ▸ | FLT1 | P17948 | 2/20 | 0.56 |
| ▸ | FLT3 | P36888 | 2/20 | 0.56 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.56 |
| ▸ | STK3 | Q13188 | 2/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.56 |
| ▸ | GAK | O14976 | 1/20 | 0.56 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.56 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.56 |
| ▸ | LATS1 | O95835 | 1/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.56 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.56 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6326151 | 0.91 | FGFR1 (0.62) | ZAP70FGFR1KDRPDGFRBEGFR | |
| SCHEMBL6330583 | 0.90 | FGFR1 (0.59) | ZAP70FGFR1KDRPDGFRBEGFR | |
| SCHEMBL6328942 | 0.90 | FGFR1 (0.69) | ZAP70FGFR1KDRPDGFRBEGFR | |
| SCHEMBL6327913 | 0.89 | FGFR1 (0.60) | ZAP70FGFR1KDRPDGFRBEGFR | |
| SCHEMBL6328883 | 0.89 | FGFR1 (0.76) | ZAP70FGFR1KDRPDGFRBEGFR | |
| SCHEMBL6328620 | 0.89 | AURKA (0.75) | ZAP70FGFR1KDRPDGFRBEGFR | |
| SCHEMBL6331079 | 0.88 | FGFR1 (0.62) | ZAP70FGFR1KDRPDGFRBEGFR | |
| SCHEMBL6328862 | 0.87 | KDR (0.66) | ZAP70FGFR1KDRPDGFRBEGFR | |
| SCHEMBL6330204 | 0.87 | FGFR1 (0.66) | ZAP70FGFR1KDRPDGFRBEGFR | |
| SCHEMBL4415638 | 0.86 | KDR (0.78) | ZAP70FGFR1KDRPDGFRBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050032871-A1 | Sulfonylated pyrrole-2-indolinone derivatives as kinase inhibitors | SUGEN, INC. | 2005-02-10 | — | — | US | claimed |
| US-20050032871-A1 | Sulfonylated pyrrole-2-indolinone derivatives as kinase inhibitors | SUGEN, INC. | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032871-A1 | Sulfonylated pyrrole-2-indolinone derivatives as kinase inhibitors | MAP3K20, CDK20, STK10 | ZAP70 291/4885FGFR1 382/4885KDR 974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.