Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 9/20 | 0.58 |
| ▸ | CDK1 | P06493 | 9/20 | 0.58 |
| ▸ | CCNB1 | P14635 | 9/20 | 0.58 |
| ▸ | GSK3B | P49841 | 9/20 | 0.58 |
| ▸ | CCNB3 | Q8WWL7 | 9/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 8/20 | 0.58 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.58 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 3/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL152280 | 0.86 | CCNB2 (0.51) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL624585 | 0.84 | CCNB2 (0.54) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL29622057 | 0.84 | CCNB2 (0.54) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL10713946 | 0.81 | CCNB2 (0.47) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL6323945 | 0.80 | JAK2 (0.49) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL10710490 | 0.80 | CCNB2 (0.48) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL10712776 | 0.80 | AHR (0.53) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL6321462 | 0.80 | CCNB2 (0.48) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL5843496 | 0.79 | JAK2 (0.51) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL6324288 | 0.79 | CCNB2 (0.49) | CCNB2CDK1CCNB1GSK3BCCNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861418-B2 | 4-aryl substituted indolinones | SUGEN, INC. (US) | 2005-03-01 | — | — | US | disclosed |
| US-20040157909-A1 | 4-Aryl substituted indolinones | SUGEN, INC. | 2004-08-12 | — | — | US | disclosed |
| US-6677368-B2 | 4-aryl substituted indolinones | SUGEN, INC. | 2004-01-13 | — | — | US | disclosed |
| EP-1349852-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | Sugen, Inc. (US) | 2003-10-08 | — | — | EP | disclosed |
| US-20030069297-A1 | 4-aryl substituted indolinones | SUGEN, INC. | 2003-04-10 | — | — | US | disclosed |
| WO-2002055517-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | CUI JINGRONG (US) | 2002-07-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069297-A1 | 4-aryl substituted indolinones | CDK5, CAMK4, TNK2 | CCNB2 694/4885CDK1 51/4885CCNB1 449/4885 |
| US-20040157909-A1 | 4-Aryl substituted indolinones | CDK5, CAMK4, TNK2 | CCNB2 694/4885CDK1 51/4885CCNB1 449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.