Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 3/20 | 0.54 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.44 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.44 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.43 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6328120 | 1.00 | CES1 (0.54) | CES1PRKAG1PRKAA2PRKAB1MAPT | |
| SCHEMBL6328148 | 0.90 | CES1 (0.58) | CES1PRKAG1PRKAA2PRKAB1MAPT | |
| SCHEMBL6328153 | 0.90 | CES1 (0.58) | CES1PRKAG1PRKAA2PRKAB1MAPT | |
| SCHEMBL6321121 | 0.89 | CES1 (0.54) | CES1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6321119 | 0.89 | CES1 (0.54) | CES1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL8016552 | 0.88 | CES1 (0.52) | CES1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL8016555 | 0.88 | CES1 (0.52) | CES1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6320616 | 0.86 | CES1 (0.50) | CES1PRKAG1PRKAA2PRKAB1MAPT | |
| SCHEMBL6320761 | 0.86 | CES1 (0.50) | CES1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6320618 | 0.86 | CES1 (0.50) | CES1PRKAG1PRKAA2PRKAB1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6855710-B2 | Substituted indolines with an inhibitory effect on various kinases and complexes of CDKs | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-02-15 | — | — | US | disclosed |