Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.63 |
| ▸ | HRH1 | P35367 | 7/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | DRD3 | P35462 | 3/20 | 0.62 |
| ▸ | HTR2A | P28223 | 2/20 | 0.62 |
| ▸ | HTR2B | P41595 | 2/20 | 0.62 |
| ▸ | BLM | P54132 | 2/20 | 0.62 |
| ▸ | DRD2 | P14416 | 2/20 | 0.62 |
| ▸ | CYP2J2 | P51589 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.62 |
| ▸ | GMNN | O75496 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | EGFR | P00533 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | FYN | P06241 | 1/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.62 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6329151 | 0.88 | HRH1 (0.62) | KCNH2HRH1LMNADRD3HTR2A | |
| SCHEMBL11377990 | 0.84 | HRH1 (0.72) | KCNH2HRH1LMNADRD3HTR2A | |
| SCHEMBL2456709 | 0.81 | HRH1 (0.74) | KCNH2HRH1LMNADRD3HTR2A | |
| SCHEMBL11401175 | 0.81 | KCNH2 (0.57) | KCNH2HRH1LMNADRD3HTR2A | |
| SCHEMBL6456656 | 0.81 | HRH1 (0.62) | KCNH2HRH1LMNADRD3HTR2A | |
| SCHEMBL11367781 | 0.80 | HRH1 (0.74) | KCNH2HRH1LMNADRD3HTR2A | |
| SCHEMBL6807447 | 0.80 | KCNH2 (0.69) | KCNH2HRH1LMNADRD3HTR2A | |
| SCHEMBL13516821 | 0.80 | KCNH2 (0.83) | KCNH2HRH1LMNADRD3HTR2A | |
| SCHEMBL16345703 | 0.80 | KCNH2 (0.83) | KCNH2HRH1LMNADRD3HTR2A | |
| Methane SCHEMBL6329155 | 0.79 | HRH1 (0.55) | KCNH2HRH1LMNADRD3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050239834-A1 | Novel 4-diphenylmethyl piperidine derivatives | AVENTIS PHARMACEUTICALS INC. (US) | 2005-10-27 | — | — | US | disclosed |
| US-20040167169-A1 | Novel 4-diphenylmethyl piperidine derivatives | AVENTIS PHARMACEUTICALS INC. | 2004-08-26 | — | — | US | disclosed |
| US-20030065186-A1 | Novel 4-diphenylethyl piperidine derivatives | LING KAH HIING (US) | 2003-04-03 | — | — | US | disclosed |
| US-20020016467-A1 | Novel 4-diphenylmethyl piperdine derivatives | LING KAH HIING (US) | 2002-02-07 | — | — | US | disclosed |
| EP-0871614-A1 | ALPHA-(SUBSTITUTED ALKYLPHENYL)-4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINE BUTANOL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTI-HISTAMINES, ANTI-ALLERGY AGENTS AND BRONCHODILATORS | HOECHST MARION ROUSSEL, INC. (US) | 1998-10-21 | — | — | EP | disclosed |
| WO-1996035667-A1 | ALPHA-(SUBSTITUTED ALKYLPHENYL)-4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINE BUTANOL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTI-HISTAMINES, ANTI-ALLERGY AGENTS AND BRONCHODILATORS | Hoescht Marion Roussel, Inc. (US) | 1996-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040167169-A1 | Novel 4-diphenylmethyl piperidine derivatives | HRH4, HRH2, HRH1 | KCNH2 443/4885HRH1 3/4885LMNA 4788/4885 |
| US-20020016467-A1 | Novel 4-diphenylmethyl piperdine derivatives | HRH4, HRH2, HRH1 | KCNH2 553/4885HRH1 3/4885LMNA 4739/4885 |
| US-20050239834-A1 | Novel 4-diphenylmethyl piperidine derivatives | HRH4, HRH2, HRH1 | KCNH2 443/4885HRH1 3/4885LMNA 4788/4885 |
| US-20030065186-A1 | Novel 4-diphenylethyl piperidine derivatives | HRH4, HRH2, HRH1 | KCNH2 348/4885HRH1 3/4885LMNA 4787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.