Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 3/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828597 | 0.85 | IDO1 (0.51) | IDO1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL31728057 | 0.85 | IDO1 (0.51) | IDO1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17074980 | 0.84 | GSK3B (0.58) | MEN1KMT2AIDO1PDE4APDE4B | |
| SCHEMBL30564910 | 0.83 | JAK2 (0.53) | MEN1NPC1KMT2AIDO1PDE4A | |
| SCHEMBL3078111 | 0.83 | JAK2 (0.53) | MEN1NPC1KMT2AIDO1PDE4A | |
| SCHEMBL18025746 | 0.83 | MAPT (0.49) | GAAKMT2AIDO1PDE4APDE4B | |
| SCHEMBL18025754 | 0.83 | PDE4A (0.49) | MEN1NPC1KMT2AIDO1PDE4A | |
| SCHEMBL325218 | 0.82 | HAO1 (0.53) | HAO1MEN1NPC1GAAKMT2A | |
| SCHEMBL18025745 | 0.79 | PDE4A (0.55) | MEN1NPC1GAAKMT2AIDO1 | |
| SCHEMBL18025750 | 0.78 | PDE4A (0.51) | NPC1IDO1PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861418-B2 | 4-aryl substituted indolinones | SUGEN, INC. (US) | 2005-03-01 | — | — | US | disclosed |