Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | RET | P07949 | 3/20 | 0.46 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.46 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 4/20 | 0.43 |
| ▸ | FLT3 | P36888 | 4/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.43 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 2/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6328765 | 0.92 | RET (0.56) | KDRFGFR1PDGFRBEGFRRET | |
| SCHEMBL6328965 | 0.87 | KDR (0.58) | KDRFGFR1PDGFRBRETPRKAA1 | |
| SCHEMBL6333695 | 0.86 | PDGFRB (0.55) | KDRFGFR1PDGFRBEGFRRET | |
| SCHEMBL6330154 | 0.85 | KDR (0.55) | KDRFGFR1PDGFRBEGFRFLT4 | |
| SCHEMBL6326979 | 0.83 | ALK (0.50) | KDRFGFR1PDGFRBEGFRRET | |
| SCHEMBL6328615 | 0.82 | KDR (0.49) | KDRFGFR1PDGFRBEGFRRET | |
| SCHEMBL6326803 | 0.81 | RET (0.56) | KDRFGFR1PDGFRBEGFRRET | |
| SCHEMBL6327010 | 0.81 | ALK (0.59) | KDRFGFR1PDGFRBEGFRRET | |
| SCHEMBL6327563 | 0.80 | RET (0.58) | KDRFGFR1PDGFRBEGFRRET | |
| SCHEMBL6328172 | 0.79 | KDR (0.65) | KDRFGFR1PDGFRBEGFRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050032871-A1 | Sulfonylated pyrrole-2-indolinone derivatives as kinase inhibitors | SUGEN, INC. | 2005-02-10 | — | — | US | claimed |
| US-20050032871-A1 | Sulfonylated pyrrole-2-indolinone derivatives as kinase inhibitors | SUGEN, INC. | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032871-A1 | Sulfonylated pyrrole-2-indolinone derivatives as kinase inhibitors | MAP3K20, CDK20, STK10 | KDR 974/4885FGFR1 382/4885PDGFRB 472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.