Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.74 |
| ▸ | PDE1A | P54750 | 4/20 | 0.74 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.74 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | PDE2A | O00408 | 1/20 | 0.51 |
| ▸ | PDE6D | O43924 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | PDE9A | O76083 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | PDE6A | P16499 | 1/20 | 0.51 |
| ▸ | PDE6G | P18545 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | PDE6B | P35913 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL973661 | 0.93 | PDE5A (0.86) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL5613 | 0.85 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL30493634 | 0.85 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL5902042 | 0.84 | PDE5A (0.61) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL5902282 | 0.84 | PDE5A (0.86) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL6332323 | 0.82 | PDE5A (0.86) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL5901591 | 0.82 | PDE5A (0.85) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL6332617 | 0.82 | PDE5A (0.85) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL5901813 | 0.82 | PDE5A (0.85) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL972561 | 0.80 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6838459-B1 | 7-alkyl-and cycloalkyl-substituted imidazotriazinones | BAYER AKTIENGESELLSCHAFT (DE) | 2005-01-04 | — | — | US | disclosed |