Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.58 |
| ▸ | DDB1 | Q16531 | 18/20 | 0.58 |
| ▸ | IKZF3 | Q9UKT9 | 3/20 | 0.58 |
| ▸ | TNF | P01375 | 1/20 | 0.58 |
| ▸ | IL1B | P01584 | 1/20 | 0.58 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16770151 | 0.79 | CRBN (0.57) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL283716 | 0.79 | CRBN (0.56) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL18900415 | 0.79 | CRBN (0.56) | CRBNDDB1IKZF3TNFIL1B | |
| Avadomide SCHEMBL20495228 | 0.78 | CRBN (0.90) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL29918692 | 0.77 | DDB1 (0.46) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL25233249 | 0.77 | CRBN (0.66) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL17873796 | 0.76 | DDB1 (0.64) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL29922198 | 0.76 | DDB1 (0.64) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL25279956 | 0.76 | CRBN (0.61) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL21996834 | 0.76 | CRBN (0.76) | CRBNDDB1IKZF3TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2420497-A1 | 5-substituted quinazolinone derivatives as anti-cancer agents | CELGENE CORPORATION (US) | 2012-02-22 | — | — | EP | disclosed |