Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 5/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.52 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.52 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.52 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.52 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 6/20 | 0.46 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6331027 | 0.95 | PSEN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6333630 | 0.87 | RET (0.49) | RETTLK2LMNA | |
| SCHEMBL6337029 | 0.87 | RET (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6331394 | 0.86 | RET (0.59) | FLT3RETTLK2 | |
| SCHEMBL6328845 | 0.86 | RET (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6329628 | 0.85 | RET (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6337189 | 0.84 | RET (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6337723 | 0.84 | RET (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6337690 | 0.82 | RET (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6337046 | 0.82 | RET (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009898-A1 | New substituted indolinones, their manufacture and their use as medicaments | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-01-13 | — | — | US | disclosed |
| US-6794395-B1 | Substituted indolinones, their manufacture and their use as medicaments | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009898-A1 | New substituted indolinones, their manufacture and their use as medicaments | CCNE1, CDK1, CCNI | PSEN1 2014/4885PSEN2 3090/4885APH1B 3850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.