Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | PDE1A | P54750 | 2/20 | 0.52 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.52 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | PDE6C | P51160 | 2/20 | 0.52 |
| ▸ | PDE2A | O00408 | 1/20 | 0.52 |
| ▸ | PDE6D | O43924 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | PDE9A | O76083 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | PDE6A | P16499 | 1/20 | 0.52 |
| ▸ | PDE6G | P18545 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6334164 | 0.90 | PDE5A (0.51) | PDE5AALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL6332526 | 0.88 | PDE5A (0.52) | PDE5AALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL6338632 | 0.85 | PDE5A (0.58) | PDE5AALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL6330914 | 0.84 | PDE5A (0.53) | PDE5AALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL6338179 | 0.84 | PDE5A (0.52) | PDE5AALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL6333005 | 0.83 | PDE5A (0.54) | PDE5AALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL6332090 | 0.83 | PDE5A (0.57) | PDE5AALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL6331957 | 0.82 | PDE5A (0.64) | PDE5AALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL6198109 | 0.82 | PDE5A (0.56) | PDE5AALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL6332578 | 0.82 | PDE5A (0.68) | PDE5APDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6916927-B2 | Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine 3′,5′-monophosphate phosphodiesterase (cGMP-PDE5) for the treatment of sexual dysfunction | PFIZER INC. | 2005-07-12 | — | — | US | disclosed |
| US-20040180944-A1 | Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterase (cGMP-PDE5) for the treatment of sexual dysfunction | PFIZER INC | 2004-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180944-A1 | Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterase (cGMP-PDE5) for the treatment of sexual dysfunction | PDE5A, PDE3A, PDE3B | PDE5A 1/4885ALDH1A1 266/4885KMT2A 4191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.