Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 8/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL632618 | 0.88 | CRBN (0.40) | CRBNHDAC6HDAC1 | |
| SCHEMBL632597 | 0.85 | CRBN (0.39) | CRBNHDAC6HDAC1 | |
| SCHEMBL632924 | 0.85 | CRBN (0.41) | CRBNHDAC6HDAC1 | |
| SCHEMBL632708 | 0.82 | CRBN (0.39) | CRBNHDAC6HDAC1 | |
| SCHEMBL633493 | 0.82 | HDAC6 (0.37) | CRBNHDAC6HDAC1 | |
| SCHEMBL632688 | 0.81 | CRBN (0.56) | CRBNHDAC6HDAC1 | |
| SCHEMBL632680 | 0.80 | GAA (0.44) | CRBN | |
| SCHEMBL633939 | 0.78 | CRBN (0.36) | CRBNHDAC6HDAC1 | |
| SCHEMBL632683 | 0.78 | CRBN (0.38) | CRBN | |
| SCHEMBL3340805 | 0.78 | HDAC6 (0.39) | CRBNHDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2093228-B1 | PYRROLINE-2-ONE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | TIANJIN HEMAY BIO TECH CO LTD (CN) | 2012-02-22 | — | — | EP | disclosed |
| EP-2093228-A1 | PYRROLINE-2-ONE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | Tianjin Hemey Bio-Tech Co., Ltd. (CN) | 2009-08-26 | — | — | EP | disclosed |