Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.34 |
| ▸ | CTSA | P10619 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10204383 | 0.92 | MAPK14 (0.45) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL10204364 | 0.92 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL10202435 | 0.91 | MAPK14 (0.43) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL12124794 | 0.91 | MAPK14 (0.43) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL1066948 | 0.91 | MAPK14 (0.45) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL12124870 | 0.90 | MAPK14 (0.43) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL10202434 | 0.90 | MAPK13 (0.43) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL1063681 | 0.90 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL1083107 | 0.89 | MAPK13 (0.42) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL1065873 | 0.89 | MAPK13 (0.42) | MAPK14MAPK13MAPK12MAPK11KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050203109-A1 | Novel Compounds | SMITHKLINE BEECHAM CORPORATION | 2005-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203109-A1 | Novel Compounds | MAPKAPK2, CREBBP, CDC42BPB | MAPK14 42/4885MAPK13 43/4885MAPK12 85/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.