Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 8/20 | 0.54 |
| ▸ | BRAF | P15056 | 7/20 | 0.54 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.39 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL633659 | 0.86 | KIT (0.69) | KITBRAFKDRALDH1A1MAPT | |
| SCHEMBL633881 | 0.86 | KDR (0.64) | KITBRAFKDRMAPTKDM4E | |
| SCHEMBL633921 | 0.76 | KDR (0.64) | KITBRAFKDRMAPTPOLB | |
| SCHEMBL13409673 | 0.72 | CYP3A4 (0.49) | KITBRAFKDRALDH1A1MAPT | |
| SCHEMBL633692 | 0.72 | KDR (0.45) | KITBRAFKDRALDH1A1MAPT | |
| SCHEMBL634287 | 0.71 | KIT (0.70) | KITBRAFKDRMAPTKDM4E | |
| SCHEMBL5821055 | 0.70 | KIT (1.00) | KITBRAF | |
| SCHEMBL3363670 | 0.69 | BRAF (0.67) | KITBRAFKDRRAF1LCK | |
| SCHEMBL5807439 | 0.69 | KIT (0.80) | KITBRAF | |
| SCHEMBL5793670 | 0.69 | KIT (0.77) | KITBRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590328-B1 | (2-CARBOXAMIDO) (3-AMINO) THIOPHENE COMPOUNDS | OSI PHARM INC (US) | 2012-02-22 | — | — | EP | claimed |