Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 20/20 | 0.85 |
| ▸ | RAMP1 | O60894 | 8/20 | 0.54 |
| ▸ | RAMP3 | O60896 | 1/20 | 0.54 |
| ▸ | CALCR | P30988 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6345174 | 1.00 | CALCRL (0.85) | CALCRLRAMP1RAMP3CALCR | |
| SCHEMBL16475398 | 0.93 | CALCRL (0.78) | CALCRLRAMP1RAMP3CALCR | |
| SCHEMBL6342361 | 0.92 | CALCRL (1.00) | CALCRLRAMP1RAMP3CALCR | |
| SCHEMBL6343198 | 0.92 | CALCRL (1.00) | CALCRLRAMP1RAMP3CALCR | |
| SCHEMBL12921125 | 0.91 | CALCRL (0.84) | CALCRLRAMP1RAMP3CALCR | |
| SCHEMBL6344312 | 0.89 | CALCRL (0.75) | CALCRLRAMP1RAMP3CALCR | |
| SCHEMBL978979 | 0.87 | CALCRL (0.85) | CALCRLRAMP1RAMP3CALCR | |
| SCHEMBL979196 | 0.86 | CALCRL (0.84) | CALCRLRAMP1RAMP3CALCR | |
| SCHEMBL10071224 | 0.86 | CALCRL (0.72) | CALCRLRAMP1RAMP3CALCR | |
| SCHEMBL978556 | 0.86 | CALCRL (0.78) | CALCRLRAMP1RAMP3CALCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120121508-A1 | RADIOLABELED CGRP ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120121508-A1 | RADIOLABELED CGRP ANTAGONISTS | CALCRL, CALCR, GRPR | CALCRL 1/4885RAMP1 54/4885RAMP3 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.