Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 17/20 | 0.55 |
| ▸ | PDE1A | P54750 | 10/20 | 0.55 |
| ▸ | PDE1B | Q01064 | 10/20 | 0.55 |
| ▸ | PDE1C | Q14123 | 10/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GUSB | P08236 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5990316 | 0.82 | PDE5A (0.67) | PDE5APDE1APDE1BPDE1CMEN1 | |
| SCHEMBL5901591 | 0.78 | PDE5A (0.85) | PDE5APDE1APDE1BPDE1CMEN1 | |
| SCHEMBL6332617 | 0.78 | PDE5A (0.85) | PDE5APDE1APDE1BPDE1CMEN1 | |
| SCHEMBL5901813 | 0.78 | PDE5A (0.85) | PDE5APDE1APDE1BPDE1CMEN1 | |
| SCHEMBL6332323 | 0.77 | PDE5A (0.86) | PDE5APDE1APDE1BPDE1CMEN1 | |
| SCHEMBL2567731 | 0.77 | PDE5A (0.61) | PDE5APDE1APDE1BPDE1CMEN1 | |
| SCHEMBL972565 | 0.72 | PDE5A (0.79) | PDE5APDE1APDE1BPDE1CMEN1 | |
| SCHEMBL5613 | 0.71 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CMEN1 | |
| SCHEMBL1202 | 0.71 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CMEN1 | |
| SCHEMBL30493634 | 0.71 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6838459-B1 | 7-alkyl-and cycloalkyl-substituted imidazotriazinones | BAYER AKTIENGESELLSCHAFT (DE) | 2005-01-04 | — | — | US | disclosed |