Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.44 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 9/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 5/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 3/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 5/20 | 0.41 |
| ▸ | MTOR | P42345 | 5/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6223045 | 0.82 | PDGFRB (0.57) | PDGFRBNTRK1NTRK3NTRK2PDPK1 | |
| SCHEMBL5353143 | 0.81 | PDGFRB (0.49) | PDGFRBNTRK1NTRK3NTRK2PDPK1 | |
| SCHEMBL1941135 | 0.81 | NTRK1 (0.58) | PDGFRBNTRK1NTRK3NTRK2PDPK1 | |
| SCHEMBL1940942 | 0.81 | PDGFRB (0.58) | PDGFRBNTRK1NTRK3NTRK2PDPK1 | |
| SCHEMBL5364437 | 0.81 | NTRK1 (0.48) | PDGFRBNTRK1NTRK3NTRK2PDPK1 | |
| SCHEMBL1941376 | 0.79 | EIF2AK3 (0.51) | PDGFRBNTRK1NTRK3NTRK2PDPK1 | |
| SCHEMBL1942781 | 0.79 | PDGFRB (0.57) | PDGFRBNTRK1NTRK3NTRK2PDPK1 | |
| SCHEMBL6334905 | 0.78 | PDGFRB (0.48) | PDGFRBNTRK1NTRK3NTRK2PDPK1 | |
| SCHEMBL12076596 | 0.77 | NTRK1 (0.49) | PDGFRBNTRK1NTRK3NTRK2PDPK1 | |
| SCHEMBL1940188 | 0.76 | PDGFRB (0.59) | PDGFRBNTRK1NTRK3NTRK2PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050037999-A1 | Pyrrolopyrimidine derivatives | PFIZER INC | 2005-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050037999-A1 | Pyrrolopyrimidine derivatives | CCNA1, CCNT1, TP53 | PDGFRB 2465/4885NTRK1 4135/4885NTRK3 4212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.