Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4452504 | 0.86 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL30977156 | 0.82 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL690925 | 0.82 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL4454316 | 0.82 | AKR1B1 (0.75) | AKR1B1 | |
| SCHEMBL4456376 | 0.79 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL4451833 | 0.79 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL4458388 | 0.78 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL4455756 | 0.75 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL4455112 | 0.72 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL4455799 | 0.72 | AKR1B1 (0.73) | AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849629-B2 | Heteroaromatic substituted sulfonyl or sulfoxide or thio-pyridazinone derivatives, useful for treating diabetic complications and cardiovascular disorders | PFIZER, INC. (US) | 2005-02-01 | — | — | US | claimed |
| US-6849629-B2 | Heteroaromatic substituted sulfonyl or sulfoxide or thio-pyridazinone derivatives, useful for treating diabetic complications and cardiovascular disorders | PFIZER, INC. (US) | 2005-02-01 | — | — | US | disclosed |